Volume 20, Issue 4 (Paramedical Sciences and Military Health-winter- 2025)
Paramedical Sciences and Military Health 2025, 20(4): 40-47 |
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Yousefpour M, Ghahari L. Complementary Phytotherapeutic Strategies in Wound healing: An Integrated Analysis of Five Experimental Studies. Paramedical Sciences and Military Health 2025; 20 (4) :40-47
URL: http://jps.ajaums.ac.ir/article-1-513-en.html
URL: http://jps.ajaums.ac.ir/article-1-513-en.html
1- Department of Physiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.
2- Department of Anatomy, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran. ,l.ghahari@ajaums.ac.ir
2- Department of Anatomy, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran. ,
Abstract: (25 Views)
Introduction: Wound healing is a dynamic and multi-phase process involving inflammation, proliferation, and remodeling. Conventional therapies often target only one phase; whereas, multi-target strategies may yield superior outcomes. This study aimed to conduct an integrated analysis of the complementary effects of herbal extracts across different stages of wound healing.
Materials and Methods: Data from five independent experimental studies (2019–2025) including Achillea millefolium (yarrow), Triticum aestivum (wheat germ), Urtica dioica (nettle) and Sambucus ebulus (dwarf elder) alone or in combination of incisional, burn, and diabetic wounds in adult male Wistar rats were subjected to comparative analysis. Evaluation indicators included percentage of wound healing, angiogenesis, epidermal thickness, scar height, and histopathological findings.
Results: Nettle and yarrow extracts facilitated entry into the proliferative phase by reducing inflammatory cells and modulating the inflammatory phase. Wheat germ and dwarf elder optimized the proliferation phase by significantly increasing angiogenesis and granulation tissue formation (p<0.001). In the remodeling phase, yarrow and the dwarf elder–losartan combination significantly reduced scar height (1.12±0.09 vs. 1.82±0.15; p<0.001) and they improved collagen alignment.
Conclusion: Each of the herbal extracts had a more prominent effect in a specific repair phase. The staged use of these herbal extracts can create an integrated and effective treatment strategy for wound healing.
Materials and Methods: Data from five independent experimental studies (2019–2025) including Achillea millefolium (yarrow), Triticum aestivum (wheat germ), Urtica dioica (nettle) and Sambucus ebulus (dwarf elder) alone or in combination of incisional, burn, and diabetic wounds in adult male Wistar rats were subjected to comparative analysis. Evaluation indicators included percentage of wound healing, angiogenesis, epidermal thickness, scar height, and histopathological findings.
Results: Nettle and yarrow extracts facilitated entry into the proliferative phase by reducing inflammatory cells and modulating the inflammatory phase. Wheat germ and dwarf elder optimized the proliferation phase by significantly increasing angiogenesis and granulation tissue formation (p<0.001). In the remodeling phase, yarrow and the dwarf elder–losartan combination significantly reduced scar height (1.12±0.09 vs. 1.82±0.15; p<0.001) and they improved collagen alignment.
Conclusion: Each of the herbal extracts had a more prominent effect in a specific repair phase. The staged use of these herbal extracts can create an integrated and effective treatment strategy for wound healing.
Type of Study: Research |
Subject:
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Received: 2025/12/21 | Accepted: 2026/05/13 | Published: 2025/12/1
Received: 2025/12/21 | Accepted: 2026/05/13 | Published: 2025/12/1
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