Volume 20, Issue 4 (Paramedical Sciences and Military Health-winter- 2025)
Paramedical Sciences and Military Health 2025, 20(4): 4-10 |
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Karami M, Ghorbani M, Rafiei M, Vahidi M, Shahrokhi S Z. Assessment of the change in the expression of hsa_circ_104515 cyclic RNA in patients with type 2 diabetes compared to healthy individuals. Paramedical Sciences and Military Health 2025; 20 (4) :4-10
URL: http://jps.ajaums.ac.ir/article-1-524-en.html
URL: http://jps.ajaums.ac.ir/article-1-524-en.html
Masoumeh Karami1 
, Mehdi Ghorbani2 , Mohammad Rafiei3 , Mahmoud Vahidi2 , Seyedeh Zahra Shahrokhi *4
, Mehdi Ghorbani2 , Mohammad Rafiei3 , Mahmoud Vahidi2 , Seyedeh Zahra Shahrokhi *4
1- Department of Biochemistry, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
2- Department of Medical Laboratory Sciences, School of Paramedical Sciences, AJA University of Medical Sciences, Tehran, Iran.
3- Department of Medical Laboratory Sciences, School of Paramedical Sciences, Hamedan University of Medical Sciences, Hamedan, Iran.
4- Department of Medical Laboratory Sciences, School of Paramedical Sciences, AJA University of Medical Sciences, Tehran, Iran. ,zahra.shahrokhi70@gmail.com
2- Department of Medical Laboratory Sciences, School of Paramedical Sciences, AJA University of Medical Sciences, Tehran, Iran.
3- Department of Medical Laboratory Sciences, School of Paramedical Sciences, Hamedan University of Medical Sciences, Hamedan, Iran.
4- Department of Medical Laboratory Sciences, School of Paramedical Sciences, AJA University of Medical Sciences, Tehran, Iran. ,
Abstract: (21 Views)
Introduction: Recently, it has been reported that dysregulated levels of circRNAs may be associated with the pathogenesis of type 2 diabetes (T2DM). Accordingly, the present study aimed to determine the expression level of hsa_circ_104515 and its association with biochemical parameters in patients with T2DM, prediabetes, and control subjects.
Materials and Methods: In the present study, the expression of circRNAs in peripheral blood was determined using QRT-PCR in 20 patients with T2DM, 20 prediabetics, and 20 age- and sex-matched healthy individuals. Biochemical parameters including FBS and HbA1c were measured using routine laboratory methods.
Results: Our analysis showed that the expression level of hsa_circ_104515 has been increased in T2DM patients and prediabetics (P=0.018) compared to healthy subjects (P<0.001); however, this difference was not statistically significant. Furthermore, in Spearman correlation analysis, there was not any correlation between the expression level of hsa_circ_104515 and laboratory and anthropometric parameters including BMI (P<0.005).
Conclusion: The data of this study provided evidence that the expression level of hsa_ circ_104515 was increased in T2DM and prediabetic subjects compared to the control group.
Materials and Methods: In the present study, the expression of circRNAs in peripheral blood was determined using QRT-PCR in 20 patients with T2DM, 20 prediabetics, and 20 age- and sex-matched healthy individuals. Biochemical parameters including FBS and HbA1c were measured using routine laboratory methods.
Results: Our analysis showed that the expression level of hsa_circ_104515 has been increased in T2DM patients and prediabetics (P=0.018) compared to healthy subjects (P<0.001); however, this difference was not statistically significant. Furthermore, in Spearman correlation analysis, there was not any correlation between the expression level of hsa_circ_104515 and laboratory and anthropometric parameters including BMI (P<0.005).
Conclusion: The data of this study provided evidence that the expression level of hsa_ circ_104515 was increased in T2DM and prediabetic subjects compared to the control group.
Type of Study: Research |
Subject:
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Received: 2026/04/21 | Accepted: 2026/05/28 | Published: 2025/12/1
Received: 2026/04/21 | Accepted: 2026/05/28 | Published: 2025/12/1
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