Volume 12, Issue 1 (Paramedical Sciences and Military Health (Spring 2017) 2017)                   Paramedical Sciences and Military Health 2017, 12(1): 18-23 | Back to browse issues page

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Naderi M, Noroozi-Aghideh A, Kashanikhatib Z, Dorgalaleh A, Alizadeh S, Soleimani M. The role of vascular endothelial growth factor in factor 13 deficient patients with intracranial hemorrhage. Paramedical Sciences and Military Health. 2017; 12 (1) :18-23
URL: http://jps.ajaums.ac.ir/article-1-108-en.html
1- Ali-Ebne Abitaleb Hospital, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
2- Hematology department, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran
3- Hematology department, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
4- Hematology department, Allied Medical School, Iran University of Medical Sciences, Tehran, Iran
5- Department of Hematology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran , alizadehs@tums.ac.ir
6- Hematology department, School of Medicine, Tarbiat Modares University, Tehran, Iran
Abstract:   (2234 Views)

Introduction: Congenital factor XIII deficiency is an autosomal recessive rare bleeding disorder. Intracranial hemorrhage (ICH) is a leading cause of mortality and morbidity and occurs in up to one-third of FXIII deficient patients. The mechanisms of ICH are not well understood. In this study, the association of ICH with plasma VEGF level in FXIII deficient patients was investigated.
Methods and Materials: This study was conducted on 30 FXIII-deficient patients including the 15 patients with ICH as case and 15 patients without ICH as control group. Patients with positive family history of FXIII deficiency, abnormal clot solubility test, as well as abnormal CT scan results were included in the study. The concentration of plasma VEGF was measured by Enzyme-linked immunosorbent assay. Data analysis was performed by SPSS software.
Results: There were no significant differences in terms of gender or age between the two groups.
Twelve and 2 patients had history of one and two bleedings, respectively, and only one patient had three bleeding times in his medical history. Intraparenchymal was the most common site of ICH, and remaining had subdural and epidural hemorrhages, respectively. Concentration of plasma VEGF was higher in case than control group, however this difference was not statistically significant.
Conclusion: This study showed that ICH occurrence is not associated with plasma VEGF levels in congenital factor XIII deficiency, and some other underlying factors, besides FXIII deficiency, may contribute in ICH occurrence in these patients.

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Type of Study: Research | Subject: full articles
Received: 2017/07/19 | Accepted: 2017/07/19 | Published: 2017/07/19

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