Volume 18, Issue 3 (Paramedical Sciences and Military Health (Autumn 2023) 2024)
Paramedical Sciences and Military Health 2024, 18(3): 40-48 |
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Moradi M, Amiri F, Mohammadi parsa N. Coagulation system changes in Covid-19 inpatients during 2020-2021. Paramedical Sciences and Military Health 2024; 18 (3) :40-48
URL: http://jps.ajaums.ac.ir/article-1-387-en.html
URL: http://jps.ajaums.ac.ir/article-1-387-en.html
1- Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran
2- Department of Laboratory Sciences, Faculty of Paramedicine, Hamedan University of Medical Sciences, Hamedan, Iran ,amirif2012@gmail.com
3- Clinical Research Development Units, Besat Hospital, Hamedan University of Medical Sciences, Hamedan, Iran
2- Department of Laboratory Sciences, Faculty of Paramedicine, Hamedan University of Medical Sciences, Hamedan, Iran ,
3- Clinical Research Development Units, Besat Hospital, Hamedan University of Medical Sciences, Hamedan, Iran
Abstract: (525 Views)
Introduction: The Covid-19 disease causes many clinical and paraclinical symptoms, each of these symptoms may be effective in diagnosing the disease or determining the trend of the disease. Coagulation system changes in Covid-19 inpatients were evaluated in this study.
Methods and Materials: In a descriptive/cross-sectional study, 90 Covid-19 hospitalized patients in Hamedan were selected. Moreover, their coagulation system changes including platelet count (Plt), PT, PTT, FDP, MPV and D-Dimer were investigated on the first and seventh days of admission. Data analysis was performed with SPSS software version 26. Wilcoxon test was used quantitatively and Mc Nemar test was used qualitatively in order to compare the coagulation system changes on the first and seventh days of hospitalization.
Results: The mean age of the patients was 51.61 years. 53.33% of these patients were male and 46.64% of them were female. On the first and seventh days of hospitalization, the mean and standard deviation of coagulation system changes were as follow respectively; PT: 12.71±1.69 and 15.00±2.39 seconds (P<0.001), PTT: 33.5±8.09 and 43.11±32.31 seconds (P<0.001), Plt: 276.58±18.30 and 244.09±7.20 × 103/μl (P<0.001), MPV: 8.00±2.84 and 10.58±3.83 femtoliters (P<0.001), D-Dimre: 300.17±34.40 and 493.17±194.26 nanogram per milliliter (P<0.001). FDP≥5 in the seventh day was also higher than the first day of hospitalization (70% Vs 6.7%) respectively (P<0.001).
Discussion and Conclusion: Coagulation system of inpatients with Covid-19 undergoes significant changes from the time of admission to the seventh day. These changes include increased levels of PT, PTT, MPV, FDP and D-Dimer biomarkers and decreased platelet count.
Methods and Materials: In a descriptive/cross-sectional study, 90 Covid-19 hospitalized patients in Hamedan were selected. Moreover, their coagulation system changes including platelet count (Plt), PT, PTT, FDP, MPV and D-Dimer were investigated on the first and seventh days of admission. Data analysis was performed with SPSS software version 26. Wilcoxon test was used quantitatively and Mc Nemar test was used qualitatively in order to compare the coagulation system changes on the first and seventh days of hospitalization.
Results: The mean age of the patients was 51.61 years. 53.33% of these patients were male and 46.64% of them were female. On the first and seventh days of hospitalization, the mean and standard deviation of coagulation system changes were as follow respectively; PT: 12.71±1.69 and 15.00±2.39 seconds (P<0.001), PTT: 33.5±8.09 and 43.11±32.31 seconds (P<0.001), Plt: 276.58±18.30 and 244.09±7.20 × 103/μl (P<0.001), MPV: 8.00±2.84 and 10.58±3.83 femtoliters (P<0.001), D-Dimre: 300.17±34.40 and 493.17±194.26 nanogram per milliliter (P<0.001). FDP≥5 in the seventh day was also higher than the first day of hospitalization (70% Vs 6.7%) respectively (P<0.001).
Discussion and Conclusion: Coagulation system of inpatients with Covid-19 undergoes significant changes from the time of admission to the seventh day. These changes include increased levels of PT, PTT, MPV, FDP and D-Dimer biomarkers and decreased platelet count.
Type of Study: Research |
Subject:
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Received: 2023/11/8 | Accepted: 2023/12/5 | Published: 2024/05/21
Received: 2023/11/8 | Accepted: 2023/12/5 | Published: 2024/05/21
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