Volume 20, Issue 1 (Paramedical Sciences and Military Health 2025)
Paramedical Sciences and Military Health 2025, 20(1): 1-10 |
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Mohammadkarim A, Ahmadpour H. Dosimetric Comparison of the Common Carotid Artery in 3D Conformal Radiotherapy for Squamous Cell Carcinoma of the Tongue, Supraglottic Tumors, and Parotid Malignancies. Paramedical Sciences and Military Health 2025; 20 (1) :1-10
URL: http://jps.ajaums.ac.ir/article-1-482-en.html
URL: http://jps.ajaums.ac.ir/article-1-482-en.html
1- Radiation Science Research Center, Aja University of Medical Sciences, Tehran, Iran & Department of Radiology, Faculty of Parmedicine, Aja University of Medical Sciences, Tehran, Iran. , mohammadkarim.medphys@gmail.com
2- Department of Medical Physics, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
2- Department of Medical Physics, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Abstract: (66 Views)
Introduction: Radiotherapy plays a significant role in the treatment of head and neck cancers, impacting both tumor and adjacent normal tissues. Patients undergoing radiotherapy in the head and neck region are at risk of complications affecting normal tissues. Given the considerable radiation dose received by the common carotid artery during neck radiotherapy, this study aims to evaluate the dosimetric parameters of the carotid artery as an organ at risk.
Materials and Methods: Computerized treatment planning using 3D conformal radiotherapy was performed for 4 patients with parotid tumors, 3 patients with squamous cell carcinoma of the tongue, and 3 patients with glottic tumors, using RT-Dose software. The prescribed doses for the treatment targets of parotid, tongue, and glottic cancers were 40 Gy, 60 Gy, and 70 Gy, respectively. Dosimetric parameters—including mean dose, biologically effective dose (BED), and normal tissue complication probability (NTCP)—for the common carotid artery were evaluated from dose-volume histogram (DVH) data.
Results: Statistical analysis demonstrated significant differences in the dosimetric parameters of the common carotid artery among the three treatment groups. Furthermore, the dosimetric parameters showed significant differences when comparing between malignancy types.
Conclusion: Although the common carotid artery receives a higher mean dose and biologically effective dose per treatment session during parotid tumor radiotherapy compared to treatments for squamous cell carcinoma of the tongue and glottic tumors, the probability of normal tissue complications was significantly reduced using adaptive 3D conformal radiotherapy.
Materials and Methods: Computerized treatment planning using 3D conformal radiotherapy was performed for 4 patients with parotid tumors, 3 patients with squamous cell carcinoma of the tongue, and 3 patients with glottic tumors, using RT-Dose software. The prescribed doses for the treatment targets of parotid, tongue, and glottic cancers were 40 Gy, 60 Gy, and 70 Gy, respectively. Dosimetric parameters—including mean dose, biologically effective dose (BED), and normal tissue complication probability (NTCP)—for the common carotid artery were evaluated from dose-volume histogram (DVH) data.
Results: Statistical analysis demonstrated significant differences in the dosimetric parameters of the common carotid artery among the three treatment groups. Furthermore, the dosimetric parameters showed significant differences when comparing between malignancy types.
Conclusion: Although the common carotid artery receives a higher mean dose and biologically effective dose per treatment session during parotid tumor radiotherapy compared to treatments for squamous cell carcinoma of the tongue and glottic tumors, the probability of normal tissue complications was significantly reduced using adaptive 3D conformal radiotherapy.
Keywords: Parotid tumor, squamous cell carcinoma of the tongue, glottis malignancy, 3D conformal radiotherapy, dosimetric parameters
Type of Study: Research |
Subject:
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Received: 2025/01/31 | Accepted: 2025/02/18 | Published: 2025/03/30
Received: 2025/01/31 | Accepted: 2025/02/18 | Published: 2025/03/30
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