Volume 19, Issue 4 (Paramedical Sciences and Military Health (winter 2024) 2024)
Paramedical Sciences and Military Health 2024, 19(4): 0-0 |
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HassanPpour S, Banaee N, Khazaee Moghadam M, Yusefi M. Evaluation and Comparison of Dose Distribution by TMR10 Algorithm and Monte Carlo Simulation in Gamma Knife Treatment Planning Using a Heterogeneous Phantom. Paramedical Sciences and Military Health 2024; 19 (4)
URL: http://jps.ajaums.ac.ir/article-1-461-en.html
URL: http://jps.ajaums.ac.ir/article-1-461-en.html
1- Department of Medical Radiation, Engineering Faculty, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2- Department of Medical Radiation, Engineering Faculty, Central Tehran Branch, Islamic Azad University, Tehran, Iran ,nooshin_banaee@yahoo.com
2- Department of Medical Radiation, Engineering Faculty, Central Tehran Branch, Islamic Azad University, Tehran, Iran ,
Abstract: (77 Views)
Introduction: Cancer is the second most common cause of mortality after cardiovascular diseases. Radiotherapy involves the controlled application of ionizing radiation (X-rays, γ-rays, or particles) to destroy cancer cells by damaging their DNA while the surrounding healthy tissues have been protected. Gamma Knife® is a stereotactic radiosurgery (SRS) device with exceptional precision for treating brain tumors. Tissue heterogeneities may cause dose distribution variations in target areas, which could be overlooked by the TMR10 algorithm in Gamma Knife treatment planning. Therefore, comparing dose distributions between Gamma Knife treatment planning systems and high-accuracy methods like Monte Carlo simulation is critical for treatment precision.
Materials and Methods: To calculate dose distribution, the Gamma Knife® Icon™ was first simulated using the MCNPX Monte Carlo code. The simulated dose profile in a water phantom was validated against measurements from EBT3 radiochromic films irradiated with an 8mm collimator. Following validation, simulated dose profiles were compared with TMR10 algorithm-derived profiles in a three-layer heterogeneous phantom (bone, air and soft tissue equivalents).
Results: Discrepancies were observed between Monte Carlo-simulated and TMR10 dose profiles. While central regions showed minimal differences (<1%), peripheral regions exhibited significant deviations (up to 7%).
Discussion and Conclusion: A difference is observed in the comparison of the simulated dose profile curve and the 10TMR algorithm. This difference is due to the fact that the head density and water density are considered the same and the inhomogeneities and differences in their electron densities are ignored in this algorithm.
Materials and Methods: To calculate dose distribution, the Gamma Knife® Icon™ was first simulated using the MCNPX Monte Carlo code. The simulated dose profile in a water phantom was validated against measurements from EBT3 radiochromic films irradiated with an 8mm collimator. Following validation, simulated dose profiles were compared with TMR10 algorithm-derived profiles in a three-layer heterogeneous phantom (bone, air and soft tissue equivalents).
Results: Discrepancies were observed between Monte Carlo-simulated and TMR10 dose profiles. While central regions showed minimal differences (<1%), peripheral regions exhibited significant deviations (up to 7%).
Discussion and Conclusion: A difference is observed in the comparison of the simulated dose profile curve and the 10TMR algorithm. This difference is due to the fact that the head density and water density are considered the same and the inhomogeneities and differences in their electron densities are ignored in this algorithm.
Type of Study: Research |
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Received: 2025/03/28 | Accepted: 2025/06/1 | Published: 2024/12/30
Received: 2025/03/28 | Accepted: 2025/06/1 | Published: 2024/12/30
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