Volume 15, Issue 1 (Paramedical Sciences and Military Health (Spring 2020) 2020)                   Paramedical Sciences and Military Health 2020, 15(1): 50-55 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

An Overview of the Mitogenic RAS Effectors and its Therapeutic Approaches. Paramedical Sciences and Military Health 2020; 15 (1) :50-55
URL: http://jps.ajaums.ac.ir/article-1-215-en.html
Abstract:   (4753 Views)
Introduction: Nowadays, cancer is one of the major public health problems in the worldwide. Ras is an oncoprotein that is mainly active in types of human cancers. A mutation has been observed in  Ras gene among the more 90% of cancers including  pancreatic, lung, and colon cancers. Ras proteins (N-Ras, H-Ras, and K-Ras) act as molecular switches and are activated via GTP binding and signaling cascades to control cellular processes such as cell proliferation, differentiation, adhesion, apoptosis, migration, and division. Conversion of GTP to GDP (inactive state) is achieved through the internal GTPase activity of the Ras gene.
Methods and Material: This review article has been performed by searching Cancer, Ras, Pancreatic, Lung, and Colon keywords in various data bases such as NCBI, PubMed, Scopus, Science Direct, and Google Scholar.
Results: Mutation in the Ras results in loss of internal GTPase activity and permanently activates the protein. In this scenario, a continuous signaling is achieved by Ras  leading to cell-free growth, avoidance of cell death mechanisms, and resistance to treatment. RASSF family of effectors or Ras inhibitors are involved in many of these pathways. Thus, RASSF proteins may act as Ras death effectors. It′s inactivation may also progress the development of Ras-dependent tumors.
Discussion and Conclusion: In general, RASSF proteins represent an interesting and contradictory part of Ras that  can be used as a useful tool for targeting a large set of Ras-derived tumors.
Keywords: Cancer, Ras, Pancreatic, Lung, Colon
Full-Text [PDF 427 kb]   (2407 Downloads)    
Type of Study: review | Subject: full articles
Received: 2020/06/17 | Accepted: 2020/06/19 | Published: 2020/06/19

Add your comments about this article : Your username or Email:

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2015 All Rights Reserved | Paramedical Sciences and Military Health