Volume 20, Issue 1 (Paramedical Sciences and Military Health (Spring 2025) 2025)
Paramedical Sciences and Military Health 2025, 20(1): 20-27 |
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Ghoreishi N, Heidari R, Soltani N, Ghorbani M, Khodabandehloo F, Jahan Bakhsh Z et al . Cross-Sectional Study of the Association between COMT rs4680 and BDNF rs6265 Polymorphisms and Risk of PTSD. Paramedical Sciences and Military Health 2025; 20 (1) :20-27
URL: http://jps.ajaums.ac.ir/article-1-476-en.html
URL: http://jps.ajaums.ac.ir/article-1-476-en.html
Nima Ghoreishi1 
, Reza Heidari1 , Nadia Soltani2 , Mahdi Ghorbani3 , Fatemeh Khodabandehloo4 , Zahra Jahan Bakhsh5 , Mahmoud Vahidi6
, Reza Heidari1 , Nadia Soltani2 , Mahdi Ghorbani3 , Fatemeh Khodabandehloo4 , Zahra Jahan Bakhsh5 , Mahmoud Vahidi6
1- Research Center for Cancer Screening and Epidemiology AJA University of Medical Sciences, Tehran, Iran.
2- Department of Psychology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
3- Department of Laboratory Sciences, School of Allied Medical Sciences, Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran.
4- Department of New Technologies and Genetics, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
5- Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
6- Department of Laboratory Sciences, School of Allied Medical Sciences, Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran.
2- Department of Psychology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
3- Department of Laboratory Sciences, School of Allied Medical Sciences, Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran.
4- Department of New Technologies and Genetics, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
5- Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
6- Department of Laboratory Sciences, School of Allied Medical Sciences, Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran.
Abstract: (37 Views)
Introduction: Post-traumatic stress disorder (PTSD) is a debilitating condition, particularly prevalent among military personnel due to exposure to life-threatening events such as warfare. Symptoms include nightmares, flashbacks, insomnia, and fear, leading to impaired brain and cognitive function, which may result in reduced military performance and financial losses. In addition to environmental factors, research has shown that genetic factors contribute to the onset and severity of PTSD. This study investigated the association between COMT rs4680 and BDNF rs6265 polymorphisms and PTSD in military personnel.
Materials and Methods: This cross-sectional study included 300 Iranian military personnel. Saliva samples (2 mL) were collected for polymorphism detection. After DNA extraction, PCR-tetra ARMS was performed to identify the polymorphisms. The resulting PCR products were analyzed via electrophoresis on a 2.5% agarose gel.
Results: Among the participants, 65 were diagnosed with PTSD, while 235 served as healthy controls. Statistical analysis revealed no significant differences in age, marital status, or education between the PTSD and control groups. Genotype frequencies were compared between groups. The AA genotype of the COMT rs4680 polymorphism was more prevalent in the PTSD group than in the healthy controls (46.2% vs. 8.5%), suggesting a potential association with increased PTSD vulnerability. Additionally, a significant difference in genotype distribution was observed for the BDNF rs6265 polymorphism, with the GG genotype being more frequent in the healthy group compared to the PTSD group.
Conclusion: The findings of this study suggest that specific polymorphisms in the COMT (rs4680) and BDNF (rs6265) genes may play a significant role in susceptibility to PTSD.
Materials and Methods: This cross-sectional study included 300 Iranian military personnel. Saliva samples (2 mL) were collected for polymorphism detection. After DNA extraction, PCR-tetra ARMS was performed to identify the polymorphisms. The resulting PCR products were analyzed via electrophoresis on a 2.5% agarose gel.
Results: Among the participants, 65 were diagnosed with PTSD, while 235 served as healthy controls. Statistical analysis revealed no significant differences in age, marital status, or education between the PTSD and control groups. Genotype frequencies were compared between groups. The AA genotype of the COMT rs4680 polymorphism was more prevalent in the PTSD group than in the healthy controls (46.2% vs. 8.5%), suggesting a potential association with increased PTSD vulnerability. Additionally, a significant difference in genotype distribution was observed for the BDNF rs6265 polymorphism, with the GG genotype being more frequent in the healthy group compared to the PTSD group.
Conclusion: The findings of this study suggest that specific polymorphisms in the COMT (rs4680) and BDNF (rs6265) genes may play a significant role in susceptibility to PTSD.
Type of Study: Research |
Subject:
full articles
Received: 2025/07/9 | Accepted: 2025/08/13 | Published: 2025/04/21
Received: 2025/07/9 | Accepted: 2025/08/13 | Published: 2025/04/21
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