Volume 18, Issue 4 (Paramedical Sciences and Military Health (winter 2024) 2024)
Paramedical Sciences and Military Health 2024, 18(4): 61-77 |
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ba A, Raeisi M, Pashaei M, Alizadeh L, Roosta Y, Matin S, et al . Liquid Biopsy: An Emerging Tool for Colorectal Cancer Diagnosis and Monitoring. Paramedical Sciences and Military Health 2024; 18 (4) :61-77
URL: http://jps.ajaums.ac.ir/article-1-398-en.html
URL: http://jps.ajaums.ac.ir/article-1-398-en.html
Akbar Ba1 
, Mortaza Raeisi2 , Mohammadreza Pashaei3 , Leila Alizadeh4 , Yousef Roosta5 , Somaieh Matin6 , Abbasali Hosseinpour Feizi7 , Abbas Karimi 8
, Mortaza Raeisi2 , Mohammadreza Pashaei3 , Leila Alizadeh4 , Yousef Roosta5 , Somaieh Matin6 , Abbasali Hosseinpour Feizi7 , Abbas Karimi 8
1- Department of Molecular Medicine, Faculty of Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
2- Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
4- Gastroenterology and Liver Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5- Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran & Solid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran
6- Department of Internal Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
7- Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran & Department of Pediatrics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
8- Department of Molecular Medicine, Faculty of Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran ,karimia@tbzmed.ac.ir
2- Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
4- Gastroenterology and Liver Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5- Department of Internal Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran & Solid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran
6- Department of Internal Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
7- Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran & Department of Pediatrics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
8- Department of Molecular Medicine, Faculty of Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran ,
Abstract: (147 Views)
Introduction: This article discusses the diagnosis and monitoring of patients with colorectal cancer using liquid biopsy. Colorectal cancer is one of the most common types of cancer worldwide; moreover, its diagnosis and monitoring is of great importance due to various factors such as lifestyle, environmental and genetic factors. There are various methods for diagnosing and monitoring colorectal cancer which can be used as the basis for selecting appropriate treatment methods such as surgery, chemotherapy, targeted therapy, immunotherapy, gene therapy and combination therapies.
Methods and Materials: The current study has been performed through searching “Liquid biopsy”, “Colorectal Cancer”, “Tumor educated platelets”, “Biomarker”, and “Chemotherapy” keywords in various databases including PubMed, Scopus, Web of Science, and Google Scholar until Dec 2023. Out of the 297 articles, 49 articles were selected and they were included in the study based on the inclusion and exclusion criteria.
Results: Liquid biopsy-based analysis of circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and tumor-educated platelets (TEPs) provide useful tools for early detection, monitoring treatment response, detecting disease recurrence, and identifying tumor heterogeneity and drug resistance mechanisms in colorectal cancer.
Discussion and Conclusion: This article examines that due to the molecular characteristics of the tumor during the course of the disease and the genetic and phenotypic heterogeneity of the tumor between primary and metastatic lesions, liquid biopsy can be used as a new solution for diagnosis and monitoring of patients with colorectal cancer.
Methods and Materials: The current study has been performed through searching “Liquid biopsy”, “Colorectal Cancer”, “Tumor educated platelets”, “Biomarker”, and “Chemotherapy” keywords in various databases including PubMed, Scopus, Web of Science, and Google Scholar until Dec 2023. Out of the 297 articles, 49 articles were selected and they were included in the study based on the inclusion and exclusion criteria.
Results: Liquid biopsy-based analysis of circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and tumor-educated platelets (TEPs) provide useful tools for early detection, monitoring treatment response, detecting disease recurrence, and identifying tumor heterogeneity and drug resistance mechanisms in colorectal cancer.
Discussion and Conclusion: This article examines that due to the molecular characteristics of the tumor during the course of the disease and the genetic and phenotypic heterogeneity of the tumor between primary and metastatic lesions, liquid biopsy can be used as a new solution for diagnosis and monitoring of patients with colorectal cancer.
Type of Study: review |
Subject:
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Received: 2024/02/6 | Accepted: 2024/05/11 | Published: 2024/08/20
Received: 2024/02/6 | Accepted: 2024/05/11 | Published: 2024/08/20
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