Volume 14, Issue 4 (paramedical sciences and military health (Winter 2020) 2020)                   Paramedical Sciences and Military Health 2020, 14(4): 41-50 | Back to browse issues page

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Ansari J, Pezeshki M. XRCC3 repair role and risk of breast cancer: review article. Paramedical Sciences and Military Health 2020; 14 (4) :41-50
URL: http://jps.ajaums.ac.ir/article-1-194-en.html
1- Ayatollah Khansari Hospital, Arak University of Medical Sciences, Arak , j.ansari@arakmu.ac.ir
2- M.Sc in Genetics, Faculty of Science, University of Arak, Arak,
Abstract:   (1145 Views)
Introduction: Breast cancer is the most frequent women cancer in worldwide. Biological and epidemiological data suggest that induced damage by endogenous and exogenous factors affects the integrity and stability of DNA; moreover, it is associated with susceptibility of breast cancer. The XRCC3 gene is one of the most important and repaired genes that, by producing the XRCC3 protein, play a significant role in repairing DNA double-strand breaks and repairing them by recombination method. In other words the product of XRCC3 gene plays a key role in homologous recombination repaired of DNA double-strand breaks and it presents breast cancer with its function. The aim of this study was to investigate the relationship between XRCC3 gene and breast cancer.                 
Material & Methods: This review article has been performed by searching breast cancer, the XRCC3 gene, the double-stranded DNA repair, and the homologous recombination repair keywords in various data bases such as NCBI, PubMed, Scopus, Science Direct, and Google Scholar.
Results:Changes including mutations, deletions, displacements, duplication, and singlenucleotide polymorphisms in DNA repair genes such as XRCC3 make a difference in the repair efficiency of DNA damage. Therefore, these damages can lead to breast cancer.                       
 Discussion and conclusion: Any change in the XRCC3 gene leads to disruption of the genome repair process; therefore, it plays an important role in the development, growth and progression of breast cancer. The XRCC3 gene can be used as a marker gene in personal medicine for the prevention and screening of breast cancer, as well as a therapeutic goal in the field of breast cancer.
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Type of Study: review | Subject: full articles
Received: 2020/04/17 | Accepted: 2020/06/15 | Published: 2020/02/20

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