Volume 19, Issue 4 (Paramedical Sciences and Military Health (winter 2024) 2024)
Paramedical Sciences and Military Health 2024, 19(4): 0-0 |
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Sangi S, Mesbah Kiaei M, Bana Derakhshan H, Aligholizadeh M, Aligholizadeh M. Comparison of the Effectiveness of Gabapentin and Acetaminophen in Pain Management during Central Venous Catheter Placement in the Intensive Care Unit: A Randomized Controlled Trial. Paramedical Sciences and Military Health 2024; 19 (4)
URL: http://jps.ajaums.ac.ir/article-1-459-en.html
URL: http://jps.ajaums.ac.ir/article-1-459-en.html
Siavash Sangi1 
, Mehrdad Mesbah Kiaei2 , Homayoon Bana Derakhshan3 , Maryam Aligholizadeh *4 , Melika Aligholizadeh5
, Mehrdad Mesbah Kiaei2 , Homayoon Bana Derakhshan3 , Maryam Aligholizadeh *4 , Melika Aligholizadeh5
1- Anesthesia and Operating Room Department, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Anesthesiology and Pain Medicine, School of Medicine, Hasheminejad Kidney Center, Iran University of Medical Science, Tehran Iran
3- Assistant Professor of Medical Education, Head of Operating Room & Anesthesia Department, Faculty of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Anesthesia and Operating Room Department, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ,gholizade001@gmail.com
5- Bachelor student of Medical Laboratory Sciences, Department of Laboratory Sciences, Langroud School of Allied Medical Sciences, Guilan University of Medical Sciences, Langroud, Iran
2- Department of Anesthesiology and Pain Medicine, School of Medicine, Hasheminejad Kidney Center, Iran University of Medical Science, Tehran Iran
3- Assistant Professor of Medical Education, Head of Operating Room & Anesthesia Department, Faculty of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Anesthesia and Operating Room Department, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ,
5- Bachelor student of Medical Laboratory Sciences, Department of Laboratory Sciences, Langroud School of Allied Medical Sciences, Guilan University of Medical Sciences, Langroud, Iran
Abstract: (76 Views)
Introduction: Central venous catheterization (CVL) is a common but painful procedure in critically ill patients who are hospitalized in intensive care unit. Gabapentin, a member of the gabapentinoid, is an anticonvulsant and analgesic medication widely used to treat various neurological conditions and neuropathic pain. This drug is chemically derived from the amino acid gamma-aminobutyric acid (GABA). Acetaminophen (or paracetamol), on the other hand, is an analgesic and antipyretic drug commonly used to reduce mild to moderate pain and control fever. Both medications are considered as suitable options for managing pain associated with invasive procedures. However, the comparative efficacy of these two drugs in reducing pain during CVL placement in the intensive care unit (ICU) setting has not been fully evaluated.
Materials and Methods: In this study, 80 eligible ICU patients were selected using convenience sampling method based on predefined inclusion and exclusion criteria. They were randomly assigned to two groups of 40 patients including the gabapentin group and the acetaminophen group. The gabapentin group received a single oral dose of 600 mg, while the acetaminophen group received a 500 mg dose. Pain intensity was measured before and after drug administration, during central venous catheter (CVC) insertion, and after the procedure using the Visual Analogue Scale (VAS). Data were analyzed using SPSS software version 19, with a significance level set at P < 0.05. Statistical tests included independent t-tests for comparing mean of pain scores and chi-square tests for categorical variables.
Results: Patients were homogeneous in terms of demographic and surgical variables (P>0.05). The gabapentin group reported significantly lower mean pain scores during CVL insertion compared to the acetaminophen group (3.1 vs. 4.8, p<0.001). Additionally, patients receiving gabapentin demonstrated a reduced need for opioid analgesics (22% vs. 47%, p=0.003). Patient satisfaction with pain control was higher in the gabapentin group, and there was a significant reduction in discomfort associated with the procedure.
Conclusion: In conclusion, based on the findings of this clinical trial, gabapentin at a dose of 600mg was more effective than acetaminophen at a dose of 500mg in reducing pain levels during central venous line insertion in the Intensive Care Unit. The results suggest that gabapentin may be a valuable adjunctive analgesic agent in improving pain management strategies for critically ill patients undergoing invasive procedures in the ICU, emphasizing the importance of individualized dosing regimens for optimal pain relief. Further research is essential to validate these findings and optimize pain management protocols in the ICU setting.
Materials and Methods: In this study, 80 eligible ICU patients were selected using convenience sampling method based on predefined inclusion and exclusion criteria. They were randomly assigned to two groups of 40 patients including the gabapentin group and the acetaminophen group. The gabapentin group received a single oral dose of 600 mg, while the acetaminophen group received a 500 mg dose. Pain intensity was measured before and after drug administration, during central venous catheter (CVC) insertion, and after the procedure using the Visual Analogue Scale (VAS). Data were analyzed using SPSS software version 19, with a significance level set at P < 0.05. Statistical tests included independent t-tests for comparing mean of pain scores and chi-square tests for categorical variables.
Results: Patients were homogeneous in terms of demographic and surgical variables (P>0.05). The gabapentin group reported significantly lower mean pain scores during CVL insertion compared to the acetaminophen group (3.1 vs. 4.8, p<0.001). Additionally, patients receiving gabapentin demonstrated a reduced need for opioid analgesics (22% vs. 47%, p=0.003). Patient satisfaction with pain control was higher in the gabapentin group, and there was a significant reduction in discomfort associated with the procedure.
Conclusion: In conclusion, based on the findings of this clinical trial, gabapentin at a dose of 600mg was more effective than acetaminophen at a dose of 500mg in reducing pain levels during central venous line insertion in the Intensive Care Unit. The results suggest that gabapentin may be a valuable adjunctive analgesic agent in improving pain management strategies for critically ill patients undergoing invasive procedures in the ICU, emphasizing the importance of individualized dosing regimens for optimal pain relief. Further research is essential to validate these findings and optimize pain management protocols in the ICU setting.
Keywords: Gabapentin, Acetaminophen, Pain Management, Central Venous Catheters, Intensive Care Units
Type of Study: Research |
Subject:
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Received: 2025/03/23 | Accepted: 2025/07/3 | Published: 2024/12/30
Received: 2025/03/23 | Accepted: 2025/07/3 | Published: 2024/12/30
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