Introduction :Non alcoholic fatty liver disease is the most common chronic liver disease that it leads to fibrosis, cirrhosis and destruction of liver cells if it left untreated. Changing the lifestyle and doing physical activity can be the main factors in the prevention and treatment of this disease. The purpose of this study is to investigate the effect of physical activity on patients with non alcoholic fatty liver disease.

Materials and Methods: This study aims to investigate the effect of physical activity on patients with non alcoholic fatty liver disease. To reach this aim, 32 research articles were prepared from the scientific databases including Pub Med, Google Scholar, Scopus, Web of Science and SID during the period of 2011 to 2024. Moreover, these articles have been analyzed and the conclusion has been drawn from them.

Results: Physical activity increases AMPK, PPAR-α/γ, T3, GLP-1, UCP-1, it reverses intestinal microbiome dysbiosis ,and it decreases FGF-21, ASK-1, PAMPs and ROS in patients with fatty liver.

Conclusion: Regular physical activity as an effective non pharmacological method can be used to prevent and treat non alcoholic fatty liver disease.