Volume 20, Issue 3 (Paramedical Sciences and Military Health 2025)
Paramedical Sciences and Military Health 2025, 20(3): 37-41 |
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keshavaezi nejad A, Ghasemi F. The Effect of Oral Administration of Spirulina on Serum Levels of Liver Enzymes in Male Mice. Paramedical Sciences and Military Health 2025; 20 (3) :37-41
URL: http://jps.ajaums.ac.ir/article-1-502-en.html
URL: http://jps.ajaums.ac.ir/article-1-502-en.html
1- Department of Veterinary Medicine, Faculty of Veterinary Medicine, Islamic Azad University, Kazerun, Iran.
2- Department of Biochemistry, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran. ,Fa.ghasemei@gmail.com
2- Department of Biochemistry, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran. ,
Abstract: (25 Views)
Introduction: Drug-induced liver injury (DILI) is a major clinical concern. Spirulina is known for its antioxidant and anti-inflammatory properties. This study was designed to evaluate the effect of oral administration of Spirulina on serum levels of the liver marker enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) in male mice.
Materials and Methods: In this experimental study, twelve adult male mice were randomly divided into two equal groups (n=6): the control group (receiving normal saline via gavage) and the treatment group (receiving Spirulina via gavage at a dose of 600 mg/kg daily for 20 days). On the 21st day, blood samples were collected from the heart. After serum separation, the levels of AST, ALT, and ALP enzymes were measured using commercial kits and the photometric method. Data were analyzed using the independent t-test. A significance level of P<0.05 was considered.
Results: Spirulina administration led to a statistically significant decrease in the levels of AST (p=0.023) and ALT (p=0.026) compared to the control group.
Conclusion: It seems that Spirulina, at a dose of 600 mg/kg of body weight daily for 20 days, reduces liver enzymes in the blood.
Materials and Methods: In this experimental study, twelve adult male mice were randomly divided into two equal groups (n=6): the control group (receiving normal saline via gavage) and the treatment group (receiving Spirulina via gavage at a dose of 600 mg/kg daily for 20 days). On the 21st day, blood samples were collected from the heart. After serum separation, the levels of AST, ALT, and ALP enzymes were measured using commercial kits and the photometric method. Data were analyzed using the independent t-test. A significance level of P<0.05 was considered.
Results: Spirulina administration led to a statistically significant decrease in the levels of AST (p=0.023) and ALT (p=0.026) compared to the control group.
Conclusion: It seems that Spirulina, at a dose of 600 mg/kg of body weight daily for 20 days, reduces liver enzymes in the blood.
Type of Study: Research |
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Received: 2025/07/2 | Accepted: 2025/09/5 | Published: 2025/10/2
Received: 2025/07/2 | Accepted: 2025/09/5 | Published: 2025/10/2
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