Volume 20, Issue 2 (Paramedical Sciences and Military Health 2025)
Paramedical Sciences and Military Health 2025, 20(2): 10-19 |
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Jahanbakhsh Z, Parvizi M R, Karami Juyani A, Vahidi M, Mehri-Ardestani M, Mirzaii-Dizgah I. Evaluation of the Effectiveness of Spirulina and Moringa on Oxidant/Antioxidant Status in a Simulated Weightlessness Rat Model. Paramedical Sciences and Military Health 2025; 20 (2) :10-19
URL: http://jps.ajaums.ac.ir/article-1-488-en.html
URL: http://jps.ajaums.ac.ir/article-1-488-en.html
Zahra Jahanbakhsh1 
, Mohammad Reza Parvizi1 , Afsaneh Karami Juyani2 , Mahmoud Vahidi3 , Mojgan Mehri-Ardestani4 , Iraj Mirzaii-Dizgah *5
, Mohammad Reza Parvizi1 , Afsaneh Karami Juyani2 , Mahmoud Vahidi3 , Mojgan Mehri-Ardestani4 , Iraj Mirzaii-Dizgah *5
1- Department of Physiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.
2- Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran.
3- Department of Laboratory Sciences, School of Allied Medical Sciences, Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran.
4- Department of Persian Medicine, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.
5- Department of Physiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran. ,emirzaii@alumnus.tums.ac.ir
2- Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran.
3- Department of Laboratory Sciences, School of Allied Medical Sciences, Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran.
4- Department of Persian Medicine, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.
5- Department of Physiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran. ,
Abstract: (129 Views)
Introduction: Today, long-term space missions and military operations in stressful environments far from medical facilities have drawn researchers' attention to the role of oxidative stress and the potential of nutritional strategies to mitigate its damage. This study aimed to investigate the protective effects of Spirulina and Moringa on the oxidant/antioxidant balance in a simulated weightlessness model in rats.
Methods and Materials: In this study, 18 male rats were divided into three groups: a control group, a group receiving Spirulina (500 mg/kg), and a group receiving Moringa extract (250 mg/kg). All rats were subjected to a weightlessness model via tail suspension for 14 days. The rat's weight was measured at the beginning of the weightlessness induction period and again at the end of the two weeks. At the end of the period, blood samples were collected to measure malondialdehyde (MDA) levels and total antioxidant capacity (TAC) using a photometric method. The data were statistically analyzed using ANOVA followed by Tukey’s post hoc test.
Results: In the simulated weightlessness model, weight loss was significantly less in both treatment groups compared to the control group. The serum total antioxidant capacity (TAC) was higher in the Moringa group compared to the control group. Malondialdehyde (MDA) levels were significantly lower in both treatment groups than in the control group.
Results: Weight loss under simulated weightlessness was significantly lower in both treatment groups compared to controls. Serum TAC was significantly higher in the Moringa group relative to the control group. MDA levels were significantly reduced in both treatment groups versus controls.
Conclusion: Spirulina and Moringa improved the oxidant-antioxidant balance under space-like conditions by reducing malondialdehyde (MDA) levels and preserving antioxidant capacity. These findings demonstrate a potential role for these supplements in reducing oxidative stress-induced damage in challenging environments.
Methods and Materials: In this study, 18 male rats were divided into three groups: a control group, a group receiving Spirulina (500 mg/kg), and a group receiving Moringa extract (250 mg/kg). All rats were subjected to a weightlessness model via tail suspension for 14 days. The rat's weight was measured at the beginning of the weightlessness induction period and again at the end of the two weeks. At the end of the period, blood samples were collected to measure malondialdehyde (MDA) levels and total antioxidant capacity (TAC) using a photometric method. The data were statistically analyzed using ANOVA followed by Tukey’s post hoc test.
Results: In the simulated weightlessness model, weight loss was significantly less in both treatment groups compared to the control group. The serum total antioxidant capacity (TAC) was higher in the Moringa group compared to the control group. Malondialdehyde (MDA) levels were significantly lower in both treatment groups than in the control group.
Results: Weight loss under simulated weightlessness was significantly lower in both treatment groups compared to controls. Serum TAC was significantly higher in the Moringa group relative to the control group. MDA levels were significantly reduced in both treatment groups versus controls.
Conclusion: Spirulina and Moringa improved the oxidant-antioxidant balance under space-like conditions by reducing malondialdehyde (MDA) levels and preserving antioxidant capacity. These findings demonstrate a potential role for these supplements in reducing oxidative stress-induced damage in challenging environments.
Type of Study: Research |
Subject:
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Received: 2025/06/5 | Accepted: 2025/06/24 | Published: 2025/06/30
Received: 2025/06/5 | Accepted: 2025/06/24 | Published: 2025/06/30
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