Introduction: Dengue fever is a viral disease transmitted by Aedes albopictus and Aedes aegypti mosquitoes. This disease is expanding due to climate change and population growth. This study examines the achievements in the diagnosis, treatment, and control of this disease and it addresses the current and future challenges of this disease.

Materials and Methods: This review article has been performed to gather the most comprehensive information on dengue fever using authentic databases including PubMed,Scopus, and Google Scholar during the period of January 2013 to December 2023. Relevant articles were identified using various combinations of keywords related to dengue fever including diagnostic methods, treatment, and control of this disease. The selected articles were completely studied and evaluated after removing duplicate and irrelevant articles. Finally, 34 open-access articles, which were directly related to the research topic, were selected for in-depth analysis.

Results: Serological testing and precise molecular techniques like RT-PCR are used to diagnose dengue disease. Additionally, CRISPR-Cas technology has a high potential for a quicker and more precise diagnosis of this illness. The mainstay of treatment for dengue fever is supportive care, which emphasizes on rest and hydration to reduce symptoms. Current vaccines are not still ideal and they may have adverse effects. The primary means of controlling this disease is to lower the number of mosquito vectors by using cutting-edge techniques like genetically modified insects.

Conclusion: Recent advancements in diagnosis, particularly with the use of CRISPR-Cas technology associated with modern vector control approaches, hold promise for a brighter future in the fight against dengue fever. However, more extensive research is required in the areas of treatment and the development of safe vaccines to overcome this disease.