RT - Journal Article T1 - A review of Lasa's hemorrhagic fever JF - ajaums-jps YR - 2019 JO - ajaums-jps VO - 14 IS - 4 UR - http://jps.ajaums.ac.ir/article-1-211-en.html SP - 68 EP - 77 K1 - Hemorrhagic fever K1 - Lassa virus K1 - Epidemiology AB - Introduction: Lassa virus (LASV) is a single-stranded RNA virus that multiplies in cell cytoplasm. The virus has two major glycoproteins called GP1 and GP2, which suppress the immune system. Lassa virus proliferation is rapid and impossible to control. Methods and Materials: The present review article uses the scientific databases PubMed, Medline, Google Scholar, the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC) site and Google search engine. Results: In 1969, a Christian nurse named Laura Wayne first contracted the disease in the Lassa area. The virus has a natural reservoir of rats that secrete the virus through their feces and urine, and humans become infected through contact with animal waste. Diagnostic tests for the virus are currently PCR and serological molecular methods. Discussion and Conclusion: The World Health Organization (WHO) has declared that the virus epidemic is dangerous, and achieving vaccine is a must to protect individuals against it. Currently, some research centers are developing vaccines to prevent the virus from progressing. LA eng UL http://jps.ajaums.ac.ir/article-1-211-en.html M3 ER -