AU - SarveAhrabi, Yasin AU - Tahaye abadi, Solmaz TI - Single-step synthesis of 1,3,4-oxadiazoles containing fluorophenyl ring and evaluation of their antibacterial effect on gram-negative pathogens in vitro PT - JOURNAL ARTICLE TA - ajaums-jps JN - ajaums-jps VO - 14 VI - 4 IP - 4 4099 - http://jps.ajaums.ac.ir/article-1-189-en.html 4100 - http://jps.ajaums.ac.ir/article-1-189-en.pdf SO - ajaums-jps 4 AB  - Introduction:Nowadays, the emergence of drug resistance in bacteria is a serious threat to the health of human societies. The present study aimed to evaluate the antibacterial activity of newly synthesized 1, 3, 4-oxadiazole derivatives based on fluorophenyl functional groups ; moreover, it aimed to compare them with common antibacterial drugs. Methods and Materials: In this study, single-step derivatives of 1, 3, 4-oxadiazoles were obtained from the single-stranded reaction of N-iso-syano-imino-3, phenyl-phosphorene, carboxylic acid derivatives and 2-pyridine-carbaldehid acid in the acetonitrile solvent. The antibacterial activity of the newly synthesized compounds by repeating once on Salmonella enterica PTCC1787 and Escherichia coli PTCC1552 was investigated by well diffusion for determining minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Results: The highest levels of growth inhibition were in the combination of 4i of 22 m.m for Salmonella enterica and 24 m.m for Escherichia coli, also, the inhibitory and lethal concentrations of compound 4i had more favorable results than other compounds. Discussion and Conclusion: The synthesized compounds, in particular the compound having the functionality of d-fluorophenyl (4i), have antibacterial activity against Salmonella enterica and Escherichia coli. In addition to the antifungal activity of newly synthesized compounds, single-step synthesis is a fast and easy route for the synthesis of drug compounds ذwith more efficacy and dissipation. Furthermore, a clear vision can be presented for synthesizing and introducing new drug compounds into the medical community.. CP - IRAN IN - Yasin.ahrabi2016@gmail.com LG - eng PB - ajaums-jps PG - 1 PT - Research YR - 2019