TY - JOUR JF - ajaums-jps JO - Paramedical Sciences and Military Health VL - 14 IS - 1 PY - 2019 Y1 - 2019/5/01 TI - Synthesis and evaluation of the antifungal effects of [5-aryl-[1, 3, 4] oxadiazole-2-yl] phenyl-methanol TT - سنتز و بررسی اثرات ضد قارچی ترکیب [5-آریل- [4,3,1] اکسادیازول - 2 ایل] فنیل- متانول N2 - Introduction: Nowadays the drug resistance outbreak in fungi is considered a serious threat to the health of human societies. Oxadiazole derivatives that are high biologically applicable can be a good alternative to common anti-fungal drugs. The purpose of this study was to evaluate the anti-fungal properties of new derivatives synthesized of oxadiazole and compare them with common anti-fungal drugs on important fungi in medical study. Materials and Methods: In the present study, from single-step reaction between N-isosyano-imino-3, phenyl-phosphorene, carboxylic acid derivatives and 2-pyridine-carbaldehid in acetonitrile solvent were obtained new derivatives of oxadiazole in single step form. Anti-fungal activity of new synthesized compounds were investigated on aspergillus flavus PTCC5004 and aspergillus fumigatus PTCC 5009 by well diffusion method, determination of minimum inhibitory concentration and minimum bactericidal concentration. Results: All new synthesized compounds had promising antifungal activity against aspergillus flavus and aspergillus fumigatus. Conclusion: All new synthesized compounds have anti-fungal activity on the two Aspergillus flavus and Aspergillus fumigatus fungi. In addition to the antifungal activity of newly synthesized compounds, single-step synthesis is a fast and easy route for the synthesis of drug compounds with efficacy More and less energy, as well as a clear vision for synthesizing and introducing new drug compounds into the medical community can be presented. SP - 1 EP - 9 AU - Sarve ahrabi, Yasin AU - Hemmati Eslamlou, Parya AD - Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University of Tehran Branch, Tehran, Iran KW - Antifungal effect KW - Oxadiazole KW - Aspergillus flavus KW - Aspergillus fumigatus UR - http://jps.ajaums.ac.ir/article-1-175-en.html ER -