TY - JOUR T1 - XRCC3 repair role and risk of breast cancer: review article TT - نقش تعمیری XRCC3 و خطر بروز سرطان پستان: مقاله مروری JF - ajaums-jps JO - ajaums-jps VL - 14 IS - 4 UR - http://jps.ajaums.ac.ir/article-1-194-en.html Y1 - 2019 SP - 41 EP - 50 KW - Keywords: Breast Cancer KW - XRCC3 KW - DNA double-strand repair KW - homologous recombination repair. N2 - Introduction: Breast cancer is the most frequent women cancer in worldwide. Biological and epidemiological data suggest that induced damage by endogenous and exogenous factors affects the integrity and stability of DNA; moreover, it is associated with susceptibility of breast cancer. The XRCC3 gene is one of the most important and repaired genes that, by producing the XRCC3 protein, play a significant role in repairing DNA double-strand breaks and repairing them by recombination method. In other words the product of XRCC3 gene plays a key role in homologous recombination repaired of DNA double-strand breaks and it presents breast cancer with its function. The aim of this study was to investigate the relationship between XRCC3 gene and breast cancer. Material & Methods: This review article has been performed by searching breast cancer, the XRCC3 gene, the double-stranded DNA repair, and the homologous recombination repair keywords in various data bases such as NCBI, PubMed, Scopus, Science Direct, and Google Scholar. Results:Changes including mutations, deletions, displacements, duplication, and singlenucleotide polymorphisms in DNA repair genes such as XRCC3 make a difference in the repair efficiency of DNA damage. Therefore, these damages can lead to breast cancer. Discussion and conclusion: Any change in the XRCC3 gene leads to disruption of the genome repair process; therefore, it plays an important role in the development, growth and progression of breast cancer. The XRCC3 gene can be used as a marker gene in personal medicine for the prevention and screening of breast cancer, as well as a therapeutic goal in the field of breast cancer. M3 ER -