Showing 5 results for Liver
Danial Ashtiyani, Ali Karbalaee Mahdi,
Volume 11, Issue 2 (9-2016)
Abstract
Introduction: Molecular imaging is one of the main focuses in medical diagnostics. Nanoparticles allow us to effectively imagine the various component of molecule with high contrast. Different factors have been discussed about contrast agent nanoparticles. Moreover, some of the most important samples have been highlighted in the present study.
Methods and Materials: This research is a theoretical study and analytical method that was performed by searching Nanotechnology, Molecular imaging, Drug delivery methods, Gene therapy and contrast agent nanoparticles keywords in Google scholar, Science direct, Pubmed and Scopus websites in terms of content (content analysis). This article was written based on 10 chosen articles which were found after the search in the internet websites.
Results: Most of the nanoparticles in this study have been used to produce the new contrast agents, in particular, for molecular imaging and diagnostics cellular processes. The benefits of using these nanoparticles contain: ability of producing high contrast, ease of integration into multiple properties, long time circulation in the blood and ability of carrying high volume (such as drugs). Principles and methods of producing nanoparticles have been improved over the recent years; therefore, the more complex samples of Nano sized contrast agents have been reported such as the: paramagnetic particles, macrophages quantum dots, quantum dot, and devices that can deliver material to the atomic and molecular sections. In addition, Micro-MRI has been used to survey vascular and drug delivery.
Discussion and Conclusion: The usage of contrast agent nanoparticles provides more details about the processes and effects of a disease. Making these materials has significantly improved in the resent years by creating various functions in them. However, there are many areas for the improvement in biocompatibility, effectiveness, specific features and diagnosis. Generally, the contrast agent nanoparticles can be synthesized for specific performance and specific applications.
Reza Moradpour, Mitra Shokri, Fereshteh Talebpour Amiri, Armin Allahverdy,
Volume 12, Issue 4 (3-2017)
Abstract
Introduction: The highest electromagnetic radiation pollution is related to the radiofrequency waves of mobile phones (1). Up to 70% of these waves can be absorbed by various tissues (2). Absorption of these waves can damage the body tissues by causing oxidative stress (3). Given that melatonin plays an antioxidant role, it seems that this hormone can have a protective effect on the hepato- toxicity induced by electromagnetic waves. In this study, we investigated the protective effect of melatonin on liver tissue vulnerability by using melatonin injection in an experimental model in the presence of electromagnetic waves of mobile phones.
Methods and Materials: 32 BALB / c male mice weighting approximately 21 ± 32 g were randomly divided into 4 groups. 1) Control group received distilled water, 2) Melatonin group received daily 2mg / Kg melatonin intra-peritoneally, 3) The group of electromagnetic waves was exposed to electromagnetic waves caused by a mobile phone for 4 hours a day for 1 month, 4) Melatonin and electromagnetic waves group received daily 2mg / Kg of melatonin as an intra-peritoneal injection, one hour before exposure to the waves.
Results: The results showed that electromagnetic waves create oxidative stress (increase MDA and decrease GSH) in group 3 liver tissues. Liver enzymes (ALT, AST, ALP) also increased in group 3, which confirms liver tissue damage due to the exposure to electromagnetic waves. Changes in the histological structure of the liver tissue have also been confirmed by biochemical findings. Administration of melatonin reduced the level of oxidative stress and liver injury enzymes in group 4 and improved the liver tissue structure in the same group.
Discussion and Conclusion: The data of this study indicate that melatonin as an antioxidant has the potential to reduce the damage of the liver tissue caused by electromagnetic waves.
Mostafa Sadeghi, Moussa Abolhassani, Amir Yazdan Parast,
Volume 13, Issue 1 (6-2018)
Abstract
Introduction: Hydatid cyst is a parasitic disease caused by the accidental entrance of a tapeworm named Echinococcus granulosus into the human body. This parasitic disease can be emerged in various forms in humans. The present article reports a rare case of abdominal wall hydatid cyst followed by liver hydatid cyst surgery.
Patient Description: The patient is a 40 years old woman inhabiting in rural area who had a background of liver hydatid cyst surgery three years ago. The patient was referred with abdominal pain in RUQ region and abdominal wall mass. CT scan and sonography were performed and the recurrent hydatid cyst of liver and a new abdominal wall cyst were diagnosed in previous surgical incision.
Conclusion: Hydatid cyst can primarily infect every organ of the body and there is a recurrence risk in all the areas where infection is caused by the parasite for all the patients having surgery for hydatid cyst treatment. In this regard, the prevention of this parasitic infection in abdominal wall and cavity may inhibit the accession of such complication.
Mostafa Sadeghi, Shaghayegh Beshtar, Najme Samii,
Volume 13, Issue 2 (9-2018)
Abstract
Introduction: Over the years, renal insufficiency caused by liver disorders was an obstacle to liver transplantation in these patients. After presenting a system for the evaluation of various stages of liver disease, simultaneous transplantation of the liver and kidney is considered an appropriate therapeutic treatment in patients who are at the end stage of the liver disease and have secondary renal failure too. In this study, we report a case of simultaneous transplantation of the kidney and liver.
Patient Description: The patient was an 18 years old man who had hepatic insufficiency and recurrent renal stone that was lead to the terminal renal failure. Therefore, he has been undergoing hemodialysis from the previous 8 months ago. After examining the patient, he became a candidate for the simultaneous kidney and liver transplantation.
Results: The patient was placed in the position of spinal and general anesthesia was performed after receiving her in the operation room. First, the kidney transplantation team performed the surgical intervention by cutting the Gibson surgery on the left side of the patient. Then, a liver transplantation was performed with Chemokine anesthesia and the donated liver was transplanted. After the operation, the patient was transferred to the intensive care unit for further care.
Conclusion: Given the rising life expectancy in patients undergoing simultaneous multi organs transplantations, nowadays simultaneous transplantation of kidney and liver is considered as a selective method among patients with liver insufficiency that should be considered by professionals in this field.
Mohammad Babaei, Ameneh Pourrahim, Marefat Siahkohian, Farnaz Seify, Reza Farzizadeh,
Volume 19, Issue 2 (6-2024)
Abstract
Introduction :Non alcoholic fatty liver disease is the most common chronic liver disease that it leads to fibrosis, cirrhosis and destruction of liver cells if it left untreated. Changing the lifestyle and doing physical activity can be the main factors in the prevention and treatment of this disease. The purpose of this study is to investigate the effect of physical activity on patients with non alcoholic fatty liver disease.
Materials and Methods: This study aims to investigate the effect of physical activity on patients with non alcoholic fatty liver disease. To reach this aim, 32 research articles were prepared from the scientific databases including Pub Med, Google Scholar, Scopus, Web of Science and SID during the period of 2011 to 2024. Moreover, these articles have been analyzed and the conclusion has been drawn from them.
Results: Physical activity increases AMPK, PPAR-α/γ, T3, GLP-1, UCP-1, it reverses intestinal microbiome dysbiosis ,and it decreases FGF-21, ASK-1, PAMPs and ROS in patients with fatty liver.
Conclusion: Regular physical activity as an effective non pharmacological method can be used to prevent and treat non alcoholic fatty liver disease.