Mr Mohammad Reza Khalili Fard, Dr Rasoul Salimi, Dr Fatemeh Amiri,
Volume 16, Issue 4 (3-2021)
Abstract
Introduction: The Covid-19 virus affects the hemostasis system in infected people by causing thrombosis and it increases the level of D_dimer. This study was designed and conducted for the evaluation of correlation between D-dimer levels with disease severity in patients with Covid-19 referred to Hamedan Besat hospital.
Methods and Materials: 366 patients with Covid-19 referred to Besat Hospital in Hamadan were randomly selected in this cross-sectional and retrospective study. The severity of the disease was assessed as level 1 that is the need for intensive care and level 2 which means the need for hospital care. The collected data were analyzed through Pearson correlation and independent t-test using SPSS software version 24.
Results: The mean level of D-dimer in patients was 1.18 ± 1.01 microgram per milliliter. Disease severity was observed in 179 patients (47.3%) at level 1 and it was observed in 187 patients (52.7%) at level 2. Furthermore, the mean level of D-dimer in patients with level 1 was significantly higher than patients in level 2 (P value: 0.0001). There was a significant direct relationship between D-dimer level and hospitalization time and D-dimer level with ICU admission time (P value: 0.0001).
Discussion and Conclusion: D-dimer level is more correlates with disease severity and it impacts on duration of hospitalization and ICU hospitalization.
Dr. Maryam Moradi, Dr. Fatemeh Amiri, Dr. Narges Mohammadi Parsa,
Volume 18, Issue 3 (9-2023)
Abstract
Introduction: The Covid-19 disease causes many clinical and paraclinical symptoms, each of these symptoms may be effective in diagnosing the disease or determining the trend of the disease. Coagulation system changes in Covid-19 inpatients were evaluated in this study.
Methods and Materials: In a descriptive/cross-sectional study, 90 Covid-19 hospitalized patients in Hamedan were selected. Moreover, their coagulation system changes including platelet count (Plt), PT, PTT, FDP, MPV and D-Dimer were investigated on the first and seventh days of admission. Data analysis was performed with SPSS software version 26. Wilcoxon test was used quantitatively and Mc Nemar test was used qualitatively in order to compare the coagulation system changes on the first and seventh days of hospitalization.
Results: The mean age of the patients was 51.61 years. 53.33% of these patients were male and 46.64% of them were female. On the first and seventh days of hospitalization, the mean and standard deviation of coagulation system changes were as follow respectively; PT: 12.71±1.69 and 15.00±2.39 seconds (P<0.001), PTT: 33.5±8.09 and 43.11±32.31 seconds (P<0.001), Plt: 276.58±18.30 and 244.09±7.20 × 103/μl (P<0.001), MPV: 8.00±2.84 and 10.58±3.83 femtoliters (P<0.001), D-Dimre: 300.17±34.40 and 493.17±194.26 nanogram per milliliter (P<0.001). FDP≥5 in the seventh day was also higher than the first day of hospitalization (70% Vs 6.7%) respectively (P<0.001).
Discussion and Conclusion: Coagulation system of inpatients with Covid-19 undergoes significant changes from the time of admission to the seventh day. These changes include increased levels of PT, PTT, MPV, FDP and D-Dimer biomarkers and decreased platelet count.
