Volume 14, Issue 4 (paramedical sciences and military health (Winter 2020) 2019)
Paramedical Sciences and Military Health 2019, 14(4): 51-67 |
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Ghaffarzadeh A, Taghinejad J. A review of the genes involved in atherosclerosis. Paramedical Sciences and Military Health 2019; 14 (4) :51-67
URL: http://jps.ajaums.ac.ir/article-1-187-en.html
URL: http://jps.ajaums.ac.ir/article-1-187-en.html
1- 1) Department Of Genetic, Tabriz Branch, Islamic Azad University, Tabriz, Iran , Ayda_ghaffarzadeh@yahoo.com
2- 2) Department Of Microbiology, Malekan Branch, Islamic Azad University, Malekan, Iran
2- 2) Department Of Microbiology, Malekan Branch, Islamic Azad University, Malekan, Iran
Abstract: (2386 Views)
Introduction: Cardiovascular diseases are one of the leading causes of death in the world. Atherosclerosis is the leading cause of heart disease and death. The aim of this study is to review the genes involved in atherosclerosis.
Methods and Materials: The present review study was used with the help of Google and Google Scholar search engines and articles indexed in Pub Med scientific database. In this study cardio vascular Disease, Matrix Metalloproteinase, Atherosclerosis, Inflammatory heart, Aneurysm the keywords have been used to search among articles.
Results: The genes that cause atherosclerosis are known as matrix metalloproteinase genes. At least eight types of matrix metalloproteinase genes have been identified that are on chromosome 11, including matrix metalloproteinases 1, 3, 7, 8, 10, 12, 13 and 20, which destroy the extracellular matrix and cause plaque in the arteries.
Discussion and Conclusion: Matrix metallo proteinases play an important role in the development of cardiovascular disease. Increasing, levels of metaloproteinase cause atherosclerosis, aneurysm, myocardial infarction, and heart failure. Proper nutrition, nonsmoking, exercise, cholesterol control, blood pressure and stress will help prevent heart disease.
Methods and Materials: The present review study was used with the help of Google and Google Scholar search engines and articles indexed in Pub Med scientific database. In this study cardio vascular Disease, Matrix Metalloproteinase, Atherosclerosis, Inflammatory heart, Aneurysm the keywords have been used to search among articles.
Results: The genes that cause atherosclerosis are known as matrix metalloproteinase genes. At least eight types of matrix metalloproteinase genes have been identified that are on chromosome 11, including matrix metalloproteinases 1, 3, 7, 8, 10, 12, 13 and 20, which destroy the extracellular matrix and cause plaque in the arteries.
Discussion and Conclusion: Matrix metallo proteinases play an important role in the development of cardiovascular disease. Increasing, levels of metaloproteinase cause atherosclerosis, aneurysm, myocardial infarction, and heart failure. Proper nutrition, nonsmoking, exercise, cholesterol control, blood pressure and stress will help prevent heart disease.
Type of Study: review |
Subject:
full articles
Received: 2020/01/25 | Accepted: 2020/02/20 | Published: 2020/02/20
Received: 2020/01/25 | Accepted: 2020/02/20 | Published: 2020/02/20
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