Volume 12, Issue 4 (Paramedical Sciences and Military Health (winter 2018) 2017)
Paramedical Sciences and Military Health 2017, 12(4): 1-8 |
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Moradpour R, Shokri M, Talebpour Amiri F, Allahverdy A. Melatonin Reduces Liver Damage Caused by Mobile Radiofrequency Waves in Experimental Model of Mice. Paramedical Sciences and Military Health 2017; 12 (4) :1-8
URL: http://jps.ajaums.ac.ir/article-1-146-en.html
URL: http://jps.ajaums.ac.ir/article-1-146-en.html
1- Rouzbahan Institute of Higher Education, Sari, Iran
2- Department of Anatomy and Cell Biology, Cell and Molecular Research Center (CMRC), Faculty of Medicine, Mazandaran University of Medical Sciences (MAZUMS), Sari, Iran
3- Department of Radiology, Faculty of Paramedical Sciences, Mazandaran University of Medical Science (MAZUMS), Sari, Iran
2- Department of Anatomy and Cell Biology, Cell and Molecular Research Center (CMRC), Faculty of Medicine, Mazandaran University of Medical Sciences (MAZUMS), Sari, Iran
3- Department of Radiology, Faculty of Paramedical Sciences, Mazandaran University of Medical Science (MAZUMS), Sari, Iran
Abstract: (4883 Views)
Introduction: The highest electromagnetic radiation pollution is related to the radiofrequency waves of mobile phones (1). Up to 70% of these waves can be absorbed by various tissues (2). Absorption of these waves can damage the body tissues by causing oxidative stress (3). Given that melatonin plays an antioxidant role, it seems that this hormone can have a protective effect on the hepato- toxicity induced by electromagnetic waves. In this study, we investigated the protective effect of melatonin on liver tissue vulnerability by using melatonin injection in an experimental model in the presence of electromagnetic waves of mobile phones.
Methods and Materials: 32 BALB / c male mice weighting approximately 21 ± 32 g were randomly divided into 4 groups. 1) Control group received distilled water, 2) Melatonin group received daily 2mg / Kg melatonin intra-peritoneally, 3) The group of electromagnetic waves was exposed to electromagnetic waves caused by a mobile phone for 4 hours a day for 1 month, 4) Melatonin and electromagnetic waves group received daily 2mg / Kg of melatonin as an intra-peritoneal injection, one hour before exposure to the waves.
Results: The results showed that electromagnetic waves create oxidative stress (increase MDA and decrease GSH) in group 3 liver tissues. Liver enzymes (ALT, AST, ALP) also increased in group 3, which confirms liver tissue damage due to the exposure to electromagnetic waves. Changes in the histological structure of the liver tissue have also been confirmed by biochemical findings. Administration of melatonin reduced the level of oxidative stress and liver injury enzymes in group 4 and improved the liver tissue structure in the same group.
Discussion and Conclusion: The data of this study indicate that melatonin as an antioxidant has the potential to reduce the damage of the liver tissue caused by electromagnetic waves.
Methods and Materials: 32 BALB / c male mice weighting approximately 21 ± 32 g were randomly divided into 4 groups. 1) Control group received distilled water, 2) Melatonin group received daily 2mg / Kg melatonin intra-peritoneally, 3) The group of electromagnetic waves was exposed to electromagnetic waves caused by a mobile phone for 4 hours a day for 1 month, 4) Melatonin and electromagnetic waves group received daily 2mg / Kg of melatonin as an intra-peritoneal injection, one hour before exposure to the waves.
Results: The results showed that electromagnetic waves create oxidative stress (increase MDA and decrease GSH) in group 3 liver tissues. Liver enzymes (ALT, AST, ALP) also increased in group 3, which confirms liver tissue damage due to the exposure to electromagnetic waves. Changes in the histological structure of the liver tissue have also been confirmed by biochemical findings. Administration of melatonin reduced the level of oxidative stress and liver injury enzymes in group 4 and improved the liver tissue structure in the same group.
Discussion and Conclusion: The data of this study indicate that melatonin as an antioxidant has the potential to reduce the damage of the liver tissue caused by electromagnetic waves.
Type of Study: Research |
Subject:
full articles
Received: 2018/05/7 | Accepted: 2018/05/7 | Published: 2018/05/7
Received: 2018/05/7 | Accepted: 2018/05/7 | Published: 2018/05/7
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