Paramedical Sciences and Military Health

Introduction: Urinary tract infections are common causes of outpatient referrals to medical centers. Acute pyelonephritis is often treated by injectable antibiotics. Side effects, especially resistance to antibiotics, considered the use of non-antibiotic compounds. Resveratrol, which is found in grapes, is a powerful antioxidant, anti-inflammatory and anti-bacterial as well. In this study, the effect of resveratrol was evaluated on renal function in pyelonephritis rats.

Methods and Materials: Pyelonephritis was induced by direct injection and surgical method ATCC25922 strain of E. Coli to the right kidney in 20 male Wistar rats. Induced urinary tract infection confirmed by urine culture. In addition, after 72 hours induction of pyelonephritis, rats treated with resveratrol (10 mg/kg) and ceftriaxone via intraperitoneal injection for a week. After 6 weeks, plasma markers of renal functions such as urea, creatinine, and cystatin C determined by Hitachi biochemistry auto-analyzer.

Results: Urea, creatinine, and cystatin C significantly increased in pyelonephritis which show the impaired renal function (P<0.001). Resveratrol treatment almost neutralizes and reduces the effects of pyelonephritis and the plasma markers effectively. Resveratrol and Ceftriaxone combination therapy probably via synergistic effects improved renal function more fectively (P<0.05).

Discussion and Conclusion: The findings demonstrated that resveratrol improved renal function of pyelonephritis rats. This study provides evidence that indicate an equal protective role of Resveratrol and ceftriaxone against pyelonephritis that induced kidney damages.