1 2423-7507 AJA university of medical sciences 175 full articles Synthesis and evaluation of the antifungal effects of [5-aryl-[1, 3, 4] oxadiazole-2-yl] phenyl-methanol Sarve ahrabi Yasin b Hemmati Eslamlou Parya c b Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University of Tehran Branch, Tehran, Iran c Department of Chemistry-Physics, Faculty of Basic Sciences, Payam Nour University of Urmia, Urmia, Iran 1 5 2019 14 1 1 9 27 05 2019 Introduction: Nowadays the drug resistance outbreak in fungi is considered a serious threat to the health of human societies. Oxadiazole derivatives that are high biologically applicable can be a good alternative to common anti-fungal drugs. The purpose of this study was to evaluate the anti-fungal properties of new derivatives synthesized of oxadiazole and compare them with common anti-fungal drugs on important fungi in medical study. Materials and Methods: In the present study, from single-step reaction between N-isosyano-imino-3, phenyl-phosphorene, carboxylic acid derivatives and 2-pyridine-carbaldehid in acetonitrile solvent were obtained new derivatives of oxadiazole in single step form. Anti-fungal activity of new synthesized compounds were investigated on aspergillus flavus PTCC5004 and aspergillus fumigatus PTCC 5009 by well diffusion method, determination of minimum inhibitory concentration and minimum bactericidal concentration. Results: All new synthesized compounds had promising antifungal activity against aspergillus flavus and aspergillus fumigatus. Conclusion: All new synthesized compounds have anti-fungal activity on the two Aspergillus flavus and Aspergillus fumigatus fungi. In addition to the antifungal activity of newly synthesized compounds, single-step synthesis is a fast and easy route for the synthesis of drug compounds with efficacy More and less energy, as well as a clear vision for synthesizing and introducing new drug compounds into the medical community can be presented.
172 full articles Shift Work-induced Disorders in Selected Nurses of Educational Hospital of Sharekord University of Medical Sciences, In 2018 Yadollahi Salman d Salehi Hosein e Ansari Farshad f Solaimanian Mohammad g d Department of Healthcare Management, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. e Department of Nursing and Midwifery Department, Faculty of, sharekord University of Medical Sciences, shaherkord, Iran. f Department of Nursing and Midwifery Department, Faculty of, sharekord University of Medical Sciences, shaherkord, Iran. g Dept. of Nursing and Midwifery Department , Faculty of, sharekord University of Medical Sciences, shaherkord, iran 1 5 2019 14 1 10 17 19 05 2019 Introduction: Shift work as a social phenomenon is one of the effective factors on health workers operation which can have significant impacts on their health. Hence, the current study was conducted to determine the effect of shift working on health problems and the risk factors causing these disorders among nurses. Methods and Materials: This cross-sectional study was carried out in 120 nurses selected randomly from Ayatallah Kashani and Hajar hospitals. The data collection tool was the “Survey of Shift Worker” standard questionnaire. Data were then analyzed by SPSS 16 software using Pearson coefficient of correlation test. Results: The results showed that the highest prevalence of problems caused by shift work was related to individual, family, and social life disorders. Moreover, the compulsory selection of shift work system has reduced job satisfaction (p = 0.002). Conclusion: Based on the findings, shift working could be associated with physical complications such as cardiovascular diseases and disturbances in circadian rhythm, as well as mental disorders in nurses. Therefore, it is necessary for nursing authorities to plan shifts more precisely regarding factors such as employees’ age and job experience. 177 full articles evaluation of the Student Satisfaction about the Performance of Faculty Members of Sabzevar University of Medical Sciences in 1397-98 Esmaeilpour Maryam h Moafi Laleh i Houshmand Dalir Raziyeh j Akbarzadh Roya k h Department of Operating Room & Anesthesia, Faculty of Paramedicine, Sabzevar University of Medical Science, Sabzevar, Iran. i Department of Operating Room & Anesthesia, Faculty of Paramedicine, Sabzevar University of Medical Science, Sabzevar, Iran. j Department of Biological Statistics, Faculty of Paramedicine, Sabzevar University of Medical Science, Sabzevar, Iran. k Department of Operating Room & Anesthesia, Faculty of Paramedicine, Sabzevar University of Medical Science, Sabzevar, Iran. 1 5 2019 14 1 17 25 10 06 2019 03 08 2019 Introduction: Consultation is a helpful process in which a counselor, with all his might, is trying to create the right ability to make decision in the volunteer. Considering the necessity of the students’ educational guidance and the critical position of the consultant professor in the professional development of students, this study aimed to assess the satisfaction of students of Sabzevar University of Medical Sciences from the performance of counselors. Materials and Methods: This cross-sectional descriptive study was carried out in 350 students of Sabzevar University of Medical Sciences in a census sampling. The research instrument was a researcher-made questionnaire and reliability was performed by Cronbach’s alpha and formal and content validity. Data analysis was performed using SPSS version 20 software. Results: The results of the research show that 76.1% of the students are satisfied with the performance of counselors. The highest level of satisfaction was observed in the item of “respecting ethical principles and respect for mutual respect to students” and the least amount of satisfaction related to the item of “the possibility of timely access to the consultant’s professor”. Conclusion: The results showed that the majority of students participating in the study had a good satisfaction. Professors who are skilled and experienced can make changes, positive changes and advisories, which can create enormous changes in students. Therefore, it is suggested that university authorities, by conducting the proper planning of the selection of professors in specialized counseling, and, on the other hand, by inducing the motives of counselors, will witness the most successful process of student counseling. 174 full articles Evaluation the efficiency of health watch checkup in the diagnosis and treatment of diseases from the perspective of Hamedan police force Khajeamiri Ali Reza l Heidari Ali m l Department of Toxicology, Police University, Tehran, Iran m Police University, Tehran, Iran 1 5 2019 14 1 25 33 24 05 2019 Introduction: The health watch checkup project (HWCP) has been conducted in the armed forces since many years ago in order to increase and improve the health condition between the employees. It may be of great importance because of assessing the mental and physical health of armed forces employees; however, conducting the said checkup requires considerable money and time. To analyze the efficiency of this method, the relation between health watch checkup with the health as well as the early diagnosis and treatment of employee’s diseases has been surveyed in the Hamadan police force. Materials and Methods: In these study 113 employees among the Hamadan police force personnel has been subjected and 102 reliable questionnaires were filled and analyzed. Results: There is a positive (direct) relation between the variables of health watch checkup with early diagnosis and treatment of disease. In order to show its potency, the single variable of regression ratio analysis performed and the results showed the potency around 0.634. In addition questioner’s analysis showed that periodical checkup Conclusion: Due to positive relation between the health watch checkup and early diagnosis and treatment of diseases, regular and reliable HWCP may improve military personnel health care. 176 full articles Generalized linear mixed models:Introduction,Estimation method and Application in medical studies Fallahzadeh Hosein n Asadi Fariba o n Department of Biological Statistics, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran o Department of Biological Statistics, Faculty of Para-medicine and Health, Birjand University of Medical Sciences, Birjand, Iran 1 5 2019 14 1 33 38 08 06 2019 Introduction: In medical studies, we are often confronted with data that have been collected longitudinal or cluster. The generalized Linear mixed models that had been developed from the generalized linear models and linear mixed models- are useful methods for analyzing such data. In this paper, we introduced this models and their estimation methodologies using examples of their application in the medical field. Methods and Materials: The data of this study were related to 8525 lung cancer patients that mixed logistic regression model was used for the analysis with R software version 3.0.1 by Laplace method. Results: Regression analysis showed that age, level of experience of doctors and cancer stage were factors affecting on recovery of patients. Individual and not measured factors covered 4.03 variation of response variable. Conclusion: Generalized linear mixed models include a wide range of data, but many researchers ignored the random effects due to the lack of familiarity with these models. This mistakenly leads to some parameters have significant meanings. Correct use of these models leads to prevent many false results. 180 full articles Evaluation of new microbiological methods in the diagnosis of bloodstream infections Darb Emamie Amir p Rajabpour Mohammadreza Ghorbani Mahdi Mohajeri Iravani Mojgan p Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Department of Laboratory Sciences, Paramedical Faculty, AJA University of Medical Sciences, Tehran, Iran. Department of Anesthesiology, Paramedical Faculty, AJA University of Medical Sciences, Tehran, Iran 1 5 2019 14 1 39 55 20 06 2019 Introduction: Rapid identification and antibiotic susceptibility testing (AST) of bloodstream infections (BSIs) are essential for the initiation of antimicrobial therapy and can provide benefits for both clinical treatment and reducing costs. The aim of this study was to investigate and discuss the advantages and disadvantages of recent technologies and advances in culture-based and molecular-based methods including magnetic resonance, mass spectrometry, PCR-based methods, direct inoculation methods, and nucleic acid and peptide fluorescence hybridization. Being familiar with new microbiological methods can provide new insights for improvement of diagnosis and treatment of patients with septicemia and the diagnosis of bloodstream infections. Materials and methods: this study is a review article extracted from several databases including PubMed, Scopus, google scholar, SID and magiran. Results: Overall, in recent studies, it can be concluded that there are still limitations in the use of novel diagnostic methods to identify the microorganisms present in the bloodstream infection. One of these limitations is the lack of new equipment in laboratories, as well as the lack of skilled staff in most hospitals and clinics. Also, there has not been review articles about cost management and the use of new equipment. In sum, new diagnostic methods are increasing in use, but it is necessary to optimize them. Conclusion: Although blood culture is still the gold standard for diagnosing bloodstream infections, new methods are still in development and there are need to do more investigation about their sensitivity and specificity. 186 full articles Bioregulators, Properties and Their Applications Latifi Ali Mohammad Vahidi Mahmood Sedighian Rad Hamid Heydari Nooshin Heydari Mohammad Foad Applied Biotechnology Research Center, Baghiat-Allah University of Medical Sciences, Tehran, Iran. Lab Sciences Department, Faculty of Paramedical Sciences, AJA University of Medical Sciences, Tehran, Iran. Molecular Biology Research Center, Baghiat-Allah University of Medical Sciences, Tehran, Iran. Department of Plant Breeding and Biotechnology, Faculty of Agriculture, Tarbiat Modarres University, Tehran, Iran. DNA Molecular Identification Center, AJA University of Medical Sciences, Tehran, Iran. 1 5 2019 14 1 56 68 14 01 2020 14 01 2020 Introduction: Bioregulators are biological agents that are present in all cells and in all organisms and have a regulatory role in intracellular physiological processes and pathways and the neural mechanisms, homeostasis, immune system and endocrine secretions. Material & Methods: With the advances in neuroscience and other technologies, the study of these biological agents has gained particular attention. These agents have various applications in the medical, veterinary and agricultural fields. Therefore, pharmaceutical companies have begun manufacturing based on the biotechnological and chemical methods of these elements. Results: In addition to the general applications of Bioregulators, the military applications of these agents in the production of a new generation of biological weapons with the aim of temporarily disabling the enemy are of great interest. Discussion: Until now several bioregulators as potential factors in the production of biological weapons-debilitating have been introduced. Therefore, our Armed Forces need to become familiar with the application of these factors to maintain and enhance the preparedness and provide the necessary strategies for identifying, neutralizing, and treating those involved with these factors. Conclusion: It is suggested that bioregulators as important agents in hostage-release processes or factors that advance military objectives, both during military operations and in support of those involved in the battlefield have been mass-produced and placed at the disposal of certain forces. 171 full articles Explaining the Challenges and Solutions for Implementing Smart Systems in the Health System Haji Pour Talebi Ali Sadeghi Mojtaba Mehrabi Nahid Gholamhoseini Leila Gol Mohammadi Mobina Department of Health Information Technology, Student Research Committee, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran Department of Health Information Technology, Student Research Committee, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran Department of Health Information Technology, Student Research Committee, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran Department of Health Information Technology, Student Research Committee, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran, Iran Student Research Committee, Faculty of Nursing, AJA University of Medical Sciences, Tehran, Iran 1 5 2019 14 1 69 74 18 05 2019 Introduction: Using intelligent systems in the health system, especially artificial intelligence systems, is increasing and becoming more important. Therefore, the health system staff should choose strategies to increase their ability to use intelligent systems in the health system and to solve their challenges. The purpose of this study is to investigate the challenges and strategies for implementing intelligent systems in the health system. Methods: The present study was a systematic overview with a comprehensive search of web sites, validated journals, SIDs, PubMed, Scopus, Google Scholar search engine and related books in this area. Basic approaches to the implementation of intelligent systems especially the expert system and artificial neural network were presented in the health system. We searched several key words including the Health system, Intelligence, Electronic health records, Challenges and solutions, and their combination, in the time range of 2012 -2019. The articles were about 120 articles, of which about 75 articles having higher relation with our research were selected. Results: Using the knowledge of specialists in designing of intelligent health systems and the familiarity of professionals with health issues and challenges will help with interdisciplinary courses. The deficiencies in the country's communications infrastructure, including lack of coverage and Internet access, are among the other challenges. Other challenges include the limited technology and cost of the system. Discussion and Conclusion: Intelligent health system has many potential. But successful implementation of intelligent systems in the health system, in addition to paying attention to the principles needed for any other intelligent system, including the consideration of organizational, managerial, economic, and technical factors, also requires the items mentioned in this article, which is required by the field activists Health in the implementation of these systems.