Introduction: Cutaneous leishmaniasis is one of the world’s neglected diseases. The aim of this study was to determine the epidemiological pattern of disease in Khatam, Yazd Provincea ten-year period.

Materials and Methods: This research is a descriptive study. Data were collected from patients with a diagnosis of cutaneous leishmaniasis in health centers were under treatment and follow-up in the Khatam district during 2004-2013. And by SPSS software version 18 were used for descriptive statistics and linear regression analysis.
Results: Among a total of 1775 cases of cutaneous leishmaniasis, most of the cases were in the age group of 10-30 years.And most of these cases were men (61%). In recent years the incidence of disease was reduced and disease peak was observed in autumn.
Discussion and Conclusion: Cutaneous leishmaniasis disease is considered as a major health problem in the Khatam town. So it seems to be necessary to plan for controlling disease and measuring appropriate in order to reduce the incidence of the disease. Measures such as education, health, the fight against the reservoir, and environment can be considered disease control programs.