Volume 14, Issue 1 (Paramedical Sciences and Military Health (Spring 2019) 2019)
Paramedical Sciences and Military Health 2019, 14(1): 39-55 |
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Darb Emamie A, Rajabpour M, Ghorbani M, Mohajeri Iravani M. Evaluation of new microbiological methods in the diagnosis of bloodstream infections. Paramedical Sciences and Military Health 2019; 14 (1) :39-55
URL: http://jps.ajaums.ac.ir/article-1-180-en.html
URL: http://jps.ajaums.ac.ir/article-1-180-en.html
1- Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Laboratory Sciences, Paramedical Faculty, AJA University of Medical Sciences, Tehran, Iran. , m.ghorbani@ajaums.ac.ir
3- Department of Anesthesiology, Paramedical Faculty, AJA University of Medical Sciences, Tehran, Iran
2- Department of Laboratory Sciences, Paramedical Faculty, AJA University of Medical Sciences, Tehran, Iran. , m.ghorbani@ajaums.ac.ir
3- Department of Anesthesiology, Paramedical Faculty, AJA University of Medical Sciences, Tehran, Iran
Abstract: (2686 Views)
Introduction: Rapid identification and antibiotic susceptibility testing (AST) of bloodstream infections (BSIs) are essential for the initiation of antimicrobial therapy and can provide benefits for both clinical treatment and reducing costs. The aim of this study was to investigate and discuss the advantages and disadvantages of recent technologies and advances in culture-based and molecular-based methods including magnetic resonance, mass spectrometry, PCR-based methods, direct inoculation methods, and nucleic acid and peptide fluorescence hybridization. Being familiar with new microbiological methods can provide new insights for improvement of diagnosis and treatment of patients with septicemia and the diagnosis of bloodstream infections.
Materials and methods: this study is a review article extracted from several databases including PubMed, Scopus, google scholar, SID and magiran.
Results: Overall, in recent studies, it can be concluded that there are still limitations in the use of novel diagnostic methods to identify the microorganisms present in the bloodstream infection. One of these limitations is the lack of new equipment in laboratories, as well as the lack of skilled staff in most hospitals and clinics. Also, there has not been review articles about cost management and the use of new equipment. In sum, new diagnostic methods are increasing in use, but it is necessary to optimize them.
Conclusion: Although blood culture is still the gold standard for diagnosing bloodstream infections, new methods are still in development and there are need to do more investigation about their sensitivity and specificity.
Materials and methods: this study is a review article extracted from several databases including PubMed, Scopus, google scholar, SID and magiran.
Results: Overall, in recent studies, it can be concluded that there are still limitations in the use of novel diagnostic methods to identify the microorganisms present in the bloodstream infection. One of these limitations is the lack of new equipment in laboratories, as well as the lack of skilled staff in most hospitals and clinics. Also, there has not been review articles about cost management and the use of new equipment. In sum, new diagnostic methods are increasing in use, but it is necessary to optimize them.
Conclusion: Although blood culture is still the gold standard for diagnosing bloodstream infections, new methods are still in development and there are need to do more investigation about their sensitivity and specificity.
Keywords: Bloodstream infections, Blood culture, Molecular methods, Antimicrobial susceptibility testing
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